Geriatric Nursing
Volume 28, Issue 4 , Pages 225-229 , July 2007

Risks versus Benefits of Long-Term Proton Pump Inhibitor Therapy in the Elderly

  • Amy Schuler, BSN, RN

      Affiliations

    • AMY SCHULER, BSN, RN, is currently a geriatric nurse practitioner student at the University of Maryland School of Nursing.

References 

  1. Pilotto A, Franceschi M, Gioacchino L, et al. Clinical features of reflux esophagitis in older people: a study of 840 consecutive patients. J Am Geriatr Soc. 2006;54:1537–1542
  2. Robinson M. Proton pump inhibitors: update on their role in acid-related gastrointestinal diseases. Int J Clin Pract. 2005;59:709–715
  3. Bortz D. Atypical presentations and complications of GERD. Am J Managed Care. 1997;12:S12–S15
  4. Synder D. Evidence-based recommendations for older adults with Helicobacter pylori or those using nonsteroidal ant-inflammatory drugs. Gastroenterol Nurs. 2005;28:309–314
  5. AstraZeneca annual report. Available at: www.astrazeneca.com.sites/7/annualreports. Cited March 15, 2007.
  6. Katzung BG. In: Basic and clinical pharmacology. New York: Lange Medical Books/McGraw-Hill; 2004;p. 1037–1038p. 1040-1
  7. Tap Pharmaceuticals package insert. Available at: http://pitap.abbott.com/prevacid.pdf?noCache. Cited March 15, 2007.
  8. Vanderhoff MD, Tahboub RM. Proton pump inhibitors: an update. Clin Pharmacol. 2002;66:273–280
  9. Hazard WR, Blass JP, Halter JB. Principles of geriatric medicine and gerontology. New York: McGraw-Hill; 2003;
  10. Laheij RJ, Sturkenboom MC, Hassing RJ, et al. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. J Am Med Assoc. 2004;292:1955–1960
  11. Dial S, Delaney C, Schneider V, et al. Proton pump inhibitor use and risk of community-acquired Clostridium difficile–associated disease defined by prescription for oral vancomycin therapy. Can Med Assoc J. 2006;175:745–748
  12. Detsky ME, Juurlink DN. Does gastric acid suppression increase the risk of community-acquired pneumonia?. Can Med Assoc J. 2005;172:331
  13. MedicineNet. com. Available at: www.medicinenet.com/script/main/art.asp?articlekey=76890. Cited March 29, 2007.
  14. Porth CM. Pathophysiology: concepts of altered health state. Philadelphia: Lipincott Williams & Wilkins; 2005;
  15. National Osteoporosis Foundation. Available at: www.nof.org/ostei=oporosis/diseasefacts.html. Cited March 2, 2007.
  16. Yang Y, Lewis JD, Epstein S, et al. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006;296:2947–2953
  17. Seppa N. Bad to the bone. Sci News. 2007;171:Available at: web.ebscohost.com.proxy-hs.researchport.emd.edu. Cited March 29, 2007.
  18. Pohland CJ, Scavnicky SA, Lasky SS, et al. Lansoprazole overutilization: methods for step-down therapy. Am J Manag Care. 2003;9:353–358
  19. Lee TJ, Fennerty MB, Howden CW. Systematic review: is there excessive use of proton pump inhibitors in gastro-oesophageal reflux disease?. Aliment Pharmacol Ther. 2004;20:1241–1251
  20. National Center for Health Statistics. Available at: www.cdc.gov/nchs/fastats/older_americans.htm. Cited April 30, 2007.

PII: S0197-4572(07)00174-7

doi: 10.1016/j.gerinurse.2007.06.009

Geriatric Nursing
Volume 28, Issue 4 , Pages 225-229 , July 2007

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